IL6ST and Lyme disease: Similar to TLR2 are lipoproteins of B burgdorferi that possess cytokine-stimulating properties and maybe responsible for enhanced secretion of IL-6 by PMN and PBMC of patients with Lyme diseases [16].Increased IL-6 production by these cells from patients may enhance the inflammatory reactions leading to B burgdorferi elimination.On the other hand, elevated IL-6 activity can make a contribution to long-lasting inflammatory process in patients with Lyme disease especially thatits inhibitor—sgp130—release was unchanged.