We noticed that, increase in oxidative stress brought about by HIV infection as well as the use of therapy was paralleled by significant decreases in glutathione (GSH) level (sulfhydryls group) and albumin, as well as Vitamin C with Therapy I. Abnormally high levels of free radicals as well as the simultaneous decline of antioxidant defence mechanisms can lead to damage of cellular organelles and enzymes as well as increased lipid peroxidation. This evidence concerns the gene ALB and HIV infectious disease.