Evaluation of differential staining intensity gave the following results: KLK9, 47.2 ± 15% decrease in SSc (p < 0.05); KLK11, 69.7 ± 21% decrease in SSc (p < 0.05); KLK12, 61.6 ± 23% decrease in SSc (p < 0.05); DSG2, 62.7 ± 14% decrease in SSc (p < 0.05). The gene discussed is KLK12; the disease is systemic sclerosis.