Additionally, IFNγ secretion of CD8+ SLE TCCs was markedly lower than in CD8+ control TCCs (Figure 3a); however, due to the small number of CD8+ control clones (n = 3), the difference between patient and control TCCs (39.5 ± 29.4 pg/ml versus 376 ± 312 pg/ml) did not reach statistical significance. This evidence concerns the gene CD8A and systemic lupus erythematosus.