In the present study, we demonstrated that blood monocytes from patients with RA express high levels of IL-10R1 and M-CSFR, but not of TNF receptors, and that their TNFR1 and TNFR2 expression is effectively augmented by a combination of IL-10 and M-CSF. The gene discussed is TNFRSF1A; the disease is rheumatoid arthritis.