The overall summary RRs of the oldest versus the youngest age at menarche category show that age at menarche was negatively associated with the risk of both ER+PR+ and ER-PR- cancer (summary RRs [95% CIs]: 0.72 [0.64–0.80] and 0.84 [0.75–0.94] for ER+PR+ and ER-PR- subtypes, respectively). Here, ESR1 is linked to cancer.