INS and aspergillosis: Five DLTs were observed, one grade 3 hyperglycaemia with hyperosmolar coma at 3 mg m−2 requiring insulin and rehydration, and four DLTs at dose level of 5 mg m−2 day−1: (i) one anasarque and haematemesis, (ii) one life-threatening pulmonary aspergillosis, (iii) one skin rash and (iv) one scalp pain.