AI at the BRCA1 locus was found to be strongly associated with AI at the BRCA2 locus (P < 0.0001, OR = 7.0, 95%CI = 3.0–16.4) with 26 of 124 (21.0%) informative tumours having AI at both loci (Table 1). Here, BRCA1 is linked to neoplasm.