BRCA1 and neoplasm: This association was not statistically significant, although the TP53 mutations were found to be entirely limited to those BRCA1 methylated tumours that exhibited absent or markedly reduced BRCA1 expression, in which case the frequency of TP53 mutations becomes 55.5% (5 of 9) and the association statistically significant (P = 0.01317, OR = 6.13, 95%CI = 1.21–33.51).