In addition, we found a considerable proportion of the BRCA1 methylated tumours (7 of 13) to be of grade 3, with only one tumour of grade 1, as well as an indication of an association between BRCA1 methylation and an early age of onset (P = 0.0898) as previously reported by Wei and colleagues [34]. The gene discussed is BRCA1; the disease is neoplasm.