FCGR2A-131H is, therefore, essential for handling IgG2 immune complexes: individuals homozygous for the 131R-allele have been shown to have an increased susceptibility to various encapsulated bacterial infections, such as Neisseria meningitides, Haemophilus influenzae and Streptococcus pneumoniae [37-39]. Here, FCGR2A is linked to bacterial infectious disease.