All sera were clearly positive on ELISA and their titers were 1:12,500 in one case, 1:62,500 in six, and 1:312,500 in two, indicating that the titers of anti-RPA were as high as those of other high-affinity IgG autoantibodies in SLE. The gene discussed is RPA1; the disease is systemic lupus erythematosus.