The aim of this study was to evaluate polymorphisms in specific cytokine genes [IL1A +4845G>T, IL1B -511C>T, IL1B +3954C>T, IL1RN +2018T>C, IL4R -1902A>G, IL6-174G>C and IL10-1082G>A] in a case control model to determine any associations with breast cancer susceptibility, severity and survival. This evidence concerns the gene IL4R and breast carcinoma.