The results from our study do not support the hypothesis that the cytokine polymorphisms studied [IL1A +4845G>T, IL1B -511C>T, IL1B +3954C>T, IL1RN +2018T>C, IL4R -1902A>G, IL6-174G>C and IL10-1082G>A] are associated with breast cancer susceptibility and severity. The gene discussed is IL1RN; the disease is breast cancer.