We also found that the associationswith CRP and IL-6 were strongest and most consistent for the 8 individualswith diabetes, 14 individuals with obesity, and 4 individualswith concurrent diabetes, obesity, and hypertension, suggestingthat individuals with conditions often associated with both chronic inflammationand increased cardiac risk (Libby 2002) may be more vulnerable to the short-term proinflammatory effects of airpollution. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.