For example, an interquartileincrease in the 5-day mean PM2.5 (6.1 μg/m3) was associated with a 14% increase in CRP (95% CI, −5.4 to 37%) for all individuals and an 81% (95% CI, 21 to 172%) increase for persons with diabetes, obesity, andhypertension. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.