For example, an IQR (6.1 μg/m3) increase in the 5-day mean PM2.5 was associated with a 48% increase (95% CI, 5.3–109) inCRP for persons with obesity, a 74% increase (95% CI, 18–158) for persons with diabetes, and an 81% increase (95% CI, 21–172) in CRP for persons with diabetes, obesity, andhypertension compared with a 12% increase (95% CI, –25 to 67) for individuals without any of theseconditions. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.