This finding remains to be clarified at biochemical level, although it is conceivable that the involvement of COX-2 in the crucial biochemical pathways of tumor cell biology might play a major role: indeed, COX-2 has been reported to induce the antiapoptotic bcl-2 protein [21], and to be associated with neoangiogenesis in tumor bearing mice [22]. The gene discussed is PTGS2; the disease is neoplasm.