Genetic analysis of three NAT2 genetic variations (c.481C>T, c.590G>A and c.857G>A) in 92 colon cancer patients and 243 controls, both of unrelated Caucasians, failed to show statistically significant overall association of acetylator genotypes, in particular rapid acetylator genotypes, to colon cancer risk. Here, NAT2 is linked to malignant colon neoplasm.