These data are consistent with previous studies [12,21] but contradictory to others such as those by Moalem and colleagues who reported that HFE mutations predisposed to familial AD in ApoE E4 negative males [22] and data from Pulliam et al. that suggested that HFE mutations were associated with increased oxidative stress and Braak AD stage [7]. This evidence concerns the gene APOE and Alzheimer disease.