Lysophosphatidic acid (LPA), a phospholipid produced from malignant ovarian epithelium, can enhance the expression of CXCL8 by tumor cells and stimulate EOC cell invasion by enhancing membrane type-1 (MT1) matrix metalloproteinase (MMP) mediated activation of MMP2 [29]. The gene discussed is CXCL8; the disease is neoplasm.