FOS and acute myeloid leukemia: Western-blot and densitometric analyses of c-fos expression in PCP- and NRG1-β + PCP-treated AML 12 mouse hepatocytes for 48 h are shown in Figure 3 upon 48h of exposure, a dose-dependent upregulation of the c-fos protein was observed in concomitant treatments of PCP and NRG1-β+PCP.