Although Sandgen et al. did not observe ductal elements in their Ela-tgfα/Ela-myc and MT-100/Ela-myc double transgenic mice [53], we found that the pancreas of our double transgenic mice manifested a combination of lesions seen individually in the MT-tgfα mice and the Ela-myc mice, including proliferating ducts (fig 3A), multilocular cystic neoplasms (fig 3A and 3B), acinar cell carcinomas (fig 3C), various ductal adenocarcinomas (fig 3D, 3E and 3F) and mixed acinar and ductal carcinomas (fig 3G). This evidence concerns the gene MYC and acinar cell carcinoma.