EGFR and colorectal carcinoma: In this study, we demonstrate for the first time that LoVo CRC cells, known to lack functional IGF-1R (Lehmann et al, 1998), not only express mainly InsR-A vs InsR-B, providing an opportunity to study InsR-A without molecular manipulation , but furthermore, the InsR-A can modulate EGFR phosphorylation in the presence of gefitinib and hence, contribute to the lack of sensitivity to this inhibitor shown by the EGFR positive LoVo cells.