Indeed, differential expression of the InsR-A by cancer cells compared to their normal counterparts has been reported in colon, lung, breast (Frasca et al, 1999) and thyroid cancer clinical samples (Vella et al, 2002) and additionally, these cancer types frequently overexpress IGF-II (Quinn et al, 1996; Renehan et al, 2000). Here, IGF2 is linked to thyroid cancer.