LoVo cells expressed high levels of uncleaved pro-IGF-1R protein, represented by the band seen at ∼200 kDa and no mature receptor at 130 kDa, in contrast to A549 (non-small-cell lung carcinoma), DU145 (prostate) and MCF-7 (breast) cancer cell lines (Figure 2A). Here, IGF1R is linked to cancer.