Several other studies have reported isolation of HLA class II-restricted melanoma-specific CD4+ CTLs, including clones recognising MAGE-3, NY-ESO1 and tyrosinase epitopes (Kobayashi et al, 1998; Chaux et al, 1999; Manici et al, 1999; Zarour et al, 2000). This evidence concerns the gene TYR and melanoma.