At the invasive front of colorectal carcinoma the cytoplasmic accumulation of LAM5γ2 in neoplastic cells is the result of synergistic activation of the LAMC2 gene by β-catenin, TGFβ1, and hepatocyte-growth factor (HGF), molecules that all have been variably involved in the pathogenesis of IPF/UIP [9,18,34-36]. This evidence concerns the gene TGFB1 and idiopathic interstitial pneumonia.