Although no published study has investigated the COMT Val158Met and CYP1A1 Ile462Val polymorphisms in the progression of BBD to invasive breast cancer, previous studies of average-risk women have reported discrepant results regarding the association between the COMT Val158Met and the CYP1A1 Ile462Val polymorphisms and the risk of breast cancer [8,42]. The gene discussed is COMT; the disease is breast cancer.