We show that CD10+ human B progenitor cells express a set of Wnt ligand mRNAs (2B, 5B, 8A, 10A and 16), of which Wnt16 is of particular interest, since this gene is activated by the E2A-Pbx1 translocation in some cases of acute lymphocytic leukaemia (ALL) [28]. Here, WNT16 is linked to acute lymphoblastic leukemia.