To study this issue, we used the motility model system, murine NR6WT fibroblasts, to examine EGF-triggered events as autocrine signalling is absent in these cells in contrast to prostate carcinoma cells which present autocrine EGFR-activating signalling loops, and thus the role of EGFR signalling can be cleanly parsed. This evidence concerns the gene EGFR and prostate carcinoma.