Of note, we did not detect either collagenase-1 (MMP-1) or stromelysin-2 (MMP-10) that was seen to be upregulated in T24 bladder carcinoma cells (Itoh et al, 2006); this discrepancy is likely due to our examining the nontransformed NR6WT fibroblasts presenting a more limited set of transcription changes, although the two changes noted in the fibroblasts also were found in the cancer cells (Figure 5). This evidence concerns the gene MMP1 and cancer.