Of note, we did not detect either collagenase-1 (MMP-1) or stromelysin-2 (MMP-10) that was seen to be upregulated in T24 bladder carcinoma cells (Itoh et al, 2006); this discrepancy is likely due to our examining the nontransformed NR6WT fibroblasts presenting a more limited set of transcription changes, although the two changes noted in the fibroblasts also were found in the cancer cells (Figure 5). The gene discussed is MMP1; the disease is urinary bladder carcinoma.