The larger the number of viral particles of AddnIκB-PEG-RGD used for the infection, the higher the percentage of ICAM-1dim cells (cells that do not express significant levels of ICAM-1 protein) upon TNF-α activation, ranging from 6% for HUVECs transduced at 1.5 × 103 vp/cell to 27% for HUVECs transduced at the highest number of viral particles, 15 × 103 vp/cell. This evidence concerns the gene TNF and infection.