In addition, since adjuvant treatments are mainly aimed at controlling micrometastases, the strong Hsp90, as well as Hsp73, immunolabelling detected in neoplastic emboli appears to be remarkable, as it indicates that these HSPs are necessary to cells with metastatic potential and that the inhibition of their functions could affect the survival of such cells, which do not always show the same pattern of expression respect to the primary tumour [50]. Here, HSPA8 is linked to neoplasm.