This finding could be related to its association with glandular intermediate filaments, such as keratin polypeptides 8 and 18 [58] and the gradually reducing Hsp73 immunoreactivity, detected in in situ and stage I carcinomas, could be related to a partial loss of differentiation in neoplastic cells, which could determine a reduced expression of typical normal glandular tissue proteins. The gene discussed is HSPA8; the disease is carcinoma.