NIPBL and Cornelia de Lange syndrome: Delangin, the product of theNIPBL (Nipped-B-like) gene, is abnormally expressed in Cornelia de Lange syndrome, a rare congenital malformation that is characterized by growth and mental retardation, specific craniofacial and limb abnormalities, and abnormalities in a variety of other organs and tissues [27,28] (see [29] for a recent review).