Indeed, 13 of the 20 most heavily weighted genes were cancer-related:PLK1 (number 1 by PC1 weight ranking),CSE1L (number 2),DNMT1 (number 3),MSH6 (number 4),MCM7 (number 6),RRM1 (number 8),EZH2 (number 11),TOP2A (number 12),CSPG6 (number 15),MCM4 (number 17),MCM3 (number 18),HSPD1 (number 19), andPTHR1 (number 20). The gene discussed is TOP2A; the disease is cancer.