MSH6 and cancer: Indeed, 13 of the 20 most heavily weighted genes were cancer-related:PLK1 (number 1 by PC1 weight ranking),CSE1L (number 2),DNMT1 (number 3),MSH6 (number 4),MCM7 (number 6),RRM1 (number 8),EZH2 (number 11),TOP2A (number 12),CSPG6 (number 15),MCM4 (number 17),MCM3 (number 18),HSPD1 (number 19), andPTHR1 (number 20).