Cyclooxygenase-2 expression was also increased in atypical adenomatous hyperplasia, a possible precursor of ADC (Hida et al, 1998; Wolff et al, 1998; Hosomi et al, 2000; Hasturk et al, 2002) and in severe dysplasia and in situ carcinoma, precursors of SQCC (Mascaux et al, 2005b). Here, PTGS2 is linked to AIDS dementia complex.