In NSCLC, an increase in COX-2 expression was detected both in adenocarcinomas (ADC) and in squamous cell carcinomas (SQCC), but at a higher level in ADC than in SQCC (Hida et al, 1998; Wolff et al, 1998; Ochiai et al, 1999). The gene discussed is PTGS2; the disease is adenocarcinoma.