Against IFN-γ, only “late” sera from two R257X homozygous patients (one from ∼28 and 37 y and the other ∼17 y after onset) gave moderate to high ELISA signals—which we have never seen in MG/thymoma cases [10,11]—but they showed no detectable neutralising activity; both were strongly positive at diagnosis against IFN-α2 and IFN-ω. The gene discussed is IFNG; the disease is myasthenia gravis.