Because they are so APS1-specific and so consistent in this very variable condition, the autoantibodies against IFN-α and especially IFN-ω should be valuable diagnostically, e.g., to identify atypical or prodromal APS1 in patients with isolated candidiasis, AD, or HP [23], and perhaps also for prognosis, if they subsequently prove to predict onset time of the disease. The gene discussed is IFNA1; the disease is Alzheimer disease.