There is clearly a hierarchy of cytokines recognised in APS1, ranging from IFN-ω (100%) to IFN-α8, to IFN-α2, to IFN-β and IFN-λ1/IFN-λ2, to IL-12 and IFN-γ (<5%). This evidence concerns the gene IFNL1 and autoimmune polyendocrine syndrome type 1.