However, we saw clear neutralisation of IFN-λ1 in about two-thirds of the Finnish APS1 sera with anti-IFN-β antibodies but in very few of the others (Table 2; numerals in Figure 1A); the 11 positive patients were all AIRE R257X homozygotes. The gene discussed is IFNB1; the disease is autoimmune polyendocrine syndrome type 1.