Indeed, TIMP-2 increases growth rates of murine, bovine and human cells [50], but also inhibits tumor growth and angiogenesis in melanoma B16F10 cells [51], attenuates migration of MDA-MB23 breast cancer cells through a bone marrow fibroblast monolayer [52] and abolishes the tumor-promoting effect of fibroblasts on MCF7 cells injected with matrigel in nude mice [53]. This evidence concerns the gene TIMP2 and breast cancer.