The main limitations of all the studies that have evaluated the association between CRP and AS are similar to the previous experience in the atherosclerosis setting: variability and laboratory methodology in CRP determination [32,33]; cardiovascular risk factors and other variables known to affect CRP concentrations [34]; CRP was determined once, so longitudinal data are not available; other non-inflammatory mechanisms are likely to have an important role in the pathogenesis of degenerative aortic valve disease [19,20]; small study populations; short follow-up intervals; etcetera. This evidence concerns the gene CRP and atherosclerosis.