Overall the data in Figure 5 suggest IL-21+IL-2 induced higher frequencies of Tem cells compared to IL-2 or IL-21 alone on all three days; and by the early contraction phase of the pmel CD8+ T cell response (day 28) IL-21 and IL-21 + low-dose IL-2 induced equally higher percentages of tumor-specific Tcm cells than were stimulated in the control or IL-2 treated mice. The gene discussed is IL2; the disease is neoplasm.