When analyzing the pig insulin level at 16 wk after transplantation (before alloxan injection), it was noted that the four mice who later failed to control hyperglycemia exhibited the lowest pig insulin levels (below 120 pmol/l), whereas in all 13 grafted mice exhibiting normal blood glucose levels following alloxan treatment the pig insulin level was above 120 pmol/l before alloxan treatment. Here, INS is linked to Hyperglycemia.