Antibody 12B2 (and P4, not shown) only bound well to the scrapie-infected samples (Figure 3) indicating that, as in brain stem tissue [22], a discrimination between scrapie and BSE by dual WB staining is possible using lymphoid tissues, i.e. comparing the immunostaining of a sample for PrP-core specific antibody (e.g. 9A2 or L42) and PrPres N-terminus specific antibodies (12B2 or P4). Here, PRNP is linked to scrapie.