Among the up-regulated genes were several oncogenes (epidermal growth factor receptor (ERBB) and members of the WNT (WNT5A) and RAS families (RAP1A)), growth factors (PDGFC, EGF-related, ANKRD15, RGC32, NANOS1), cyclin D2 (CCND2), a co-factor for the hypoxia inducible factor 1A (EP300), an apoptosis inhibitor (GSPT1) and an antigen (CD24) highly expressed in small cell lung carcinoma. This evidence concerns the gene NANOS1 and small cell lung carcinoma.