CRP and pancreatitis: The inclusion criteria are the following: adult patients with a first onset of predicted severe acute pancreatitis (Imrie criteria 3 or more, CRP 150 mg/L or more, APACHE II score 8 or more) and the exclusion criteria are post-ERCP pancreatitis, malignancy, infection/sepsis caused by a second disease, intra-operative diagnosis of pancreatitis and use of probiotics during the study.