Seventy-one patients with clinically localized prostate cancer treated with radical prostatectomy were assessed by Theodorescu et al [127] to investigate whether the levels of immunoreactivity for p53, Rb, and bcl2 are better predictors of disease specific survival than conventional pathological parameters of the primary tumour, such as Gleason's score, capsular penetration, seminal vesicle invasion and percent of tumour in the specimen. The gene discussed is RB1; the disease is neoplasm.