For example, reduced ING1 expression was found in 73% of non-small cell lung cancer biopsies (Kameyama et al, 2003) and 44% of breast cancer primaries (Toyama et al, 1999), while no missense mutation were found in these lung cancer biopsies and only one missense mutation was found in 377 breast cancer carcinomas (0.27%). This evidence concerns the gene ING1 and breast carcinoma.