Table 1 summarises the results. The mRNA levels of the different biomarkers varied considerably within the tumours, from median 107 mRNA copies/18S rRNA unit for CEA to 0.05 for CEACAM7-1. CEA and CEACAM6 mRNAs were expressed at approximately equal levels in tumours and iECs while the mRNA levels for CEACAM7-1/2, CEACAM1-L, MUC2 and CK20 were significantly decreased in the tumour. Only MMP7 mRNA levels were increased in the tumour compared to iECs (Table 1). Table 2 shows the mRNA levels of the biomarkers in four CRC cell lines. The gene discussed is MMP7; the disease is colorectal carcinoma.