Arinaga and Ogawa also reported that there was no significant correlation between the VEGF-C expression level and lymph node metastasis (Arinaga et al, 2003; Ogawa et al, 2004) On the other hand, Kajita demonstrated a positive association between VEGF-C expression level and lymph node metastasis using immunohistochemical methods (Kajita et al, 2001). The gene discussed is VEGFC; the disease is metastatic malignant neoplasm in the lymph nodes.