PRKN and neuroblastoma: In NB, p53 although rarely mutated (Vogan et al, 1993), can still be functionally inactivated through cytoplasmic sequestration secondary to multiple mechanisms (Moll et al, 1995; Tweddle et al, 2003) and, among them, even to a possible binding to parkin protein (Nikolaev et al, 2003).