TYMS and neoplasm: This relationship was independent of TS status, observed in both tumours expressing low and high TS levels (p ≤ 0.03), and is consistent with the concept that most CRCs develop either along the chromosomal instability pathway associated with TP53 mutation and MSS tumours or the aberrant mismatch repair pathway associated with wild-type p53 and MSI tumours [53-56].