Agarwal et al [25] showed that administration of the FSD N-acetyl-cysteine to MDA-MB-435 breast carcinoma xenograft bearing mice resulted in angiostatin accumulation in the tumour, the induction of apoptosis in endothelial cells, a reduction of vascular density in the core of the tumour and, as a consequence, a reduced tumour growth rate. Here, PLG is linked to neoplasm.