Multivariately, COPD remained significantly associated with sTNF-R55 in sputum (OR 1.01 [1.001–1.01]) and raised plasma-LBP (OR 1.2 [1.04–1.37]), while HS expressed significantly lowered plasma-LBP (OR 0.8 [0.72–0.95]) by contrast (see Table 3). The gene discussed is LBP; the disease is chronic obstructive pulmonary disease.