According to Pruneri et al [27] and Pignataro et al [33], immunohistochemical evaluation of p27kip1 expression is a significant independent predictor of prognosis in laryngeal carcinoma, as previously stated by Fan et al. [28] who found p27kip1 expression to be the most powerful prognostic factor among gender, tumour size, lymph node metastasis, stage of disease and p53 expression. This evidence concerns the gene CDKN1B and metastatic malignant neoplasm in the lymph nodes.