CDKN1B and neoplasm: According to Pruneri et al [27] and Pignataro et al [33], immunohistochemical evaluation of p27kip1 expression is a significant independent predictor of prognosis in laryngeal carcinoma, as previously stated by Fan et al. [28] who found p27kip1 expression to be the most powerful prognostic factor among gender, tumour size, lymph node metastasis, stage of disease and p53 expression.