Conversely, most of the patients in the study by Bonneterre et al (2000) (54.4% in the anastrozole group and 55.8% in the tamoxifen group) had tumours with unknown hormone receptors, whereas Nabholtz et al (2000) reported only 11.1 and 11% and Mouridsen et al (2001) 34 and 33%, respectively (Costa and Kaufmann, 2001). The gene discussed is NR4A1; the disease is neoplasm.