The alterations identified have been further correlated with tissue neovascularization (microvessel density-MVD), assessed by CD34, vascular endothelial growth factor (VEGF) expression, p53 expression as well as with the expression of the extracellular matrix (ECM) components tenascin (TN) and fibronectin (FN) in order to elucidate their interrelationships and the possible role of this protein in tumour stroma remodeling and angiogenesis. Here, TNC is linked to neoplasm.