Acs et al. [30] reviewed the E-cadherin expression in 183 invasive mammary carcinomas and 198 carcinomas in situ and found that moderate to strong staining was present in all invasive and in situ ductal carcinomas while virtually all in situ and invasive lobular carcinomas lost expression of E-cadherin. This evidence concerns the gene CDH1 and in situ carcinoma.