To confirm the strength of our findings and because inconsistent data have been reported on the relationship between the N363S polymorphism of the GRL gene and obesity phenotypes [33, 34], after adding our own new data to previously published results, data from 5,909 unrelated subjects from a diverse ethnic backgrounds were pooled together for the analysis of BMI differences between homo-/heterozygous carriers and non-carriers of the 363S allele of the GRL gene. The gene discussed is NR3C1; the disease is obesity due to melanocortin 4 receptor deficiency.